极限挑战

RBC：亚马逊Go在未来三年的价值可能超过40亿美元。_我的网站

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    Photo: VCG
Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。北京时间1月8日晚间新闻，据外媒报道，亚马逊Go无人零售店不仅要在“便利”方面超越传统零售店，而且要在“收入”方面超越传统零售店。

二 | 亚马逊Go预计在未来三年的业务额将超过40亿美元。加拿大皇家银行资本市场（RBC Capital Markets）的分析师预计，亚马逊将比传统便利店多创造约50%的收入。分析师估计，亚马逊Go的常规订单金额约为10美元，平均每天有550名客户，平均年收入约为150万美元，不包括非营业时间。去年9月，据报道，亚马逊计划在三年内开放多达3000个亚马逊Go单元。如果亚马逊能够按时实施开发计划，那么到2021年，亚马逊Go的年销售额将达到45亿美元左右。2016年，亚马逊在西雅图推出了第一款亚马逊Go，最初只对亚马逊员工开放。

三 | 如今，亚马逊在芝加哥、旧金山和西雅图等城市开设了七个亚马逊无人驾驶便利店。去年12月，有报道称，亚马逊正在考虑将亚马逊扩展到美国的一些机场，以吸引那些匆忙但饥饿的人们。

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